Plain language summary: what symptoms should be measured in clinical studies for early-stage Parkinson's?
نویسندگان
چکیده
What is this summary about? Clinical studies test whether a new treatment safe and if the works in people who have particular condition. Most current questionnaires used clinical investigating Parkinson's measure symptoms been diagnosed for many years. This means that these existing may not be useful living with early-stage Parkinson's, where experienced can quite different to later stages, or show helpful them. The most common are involuntary shaking of parts body (“tremor”), slow movement (“bradykinesia”) stiff, inflexible muscles (“rigidity”), which worsen time. Symptoms specific fully understood research ongoing area. New measures therefore needed assess affecting especially they find troublesome. study investigated importance earlier stages their condition would appropriate future studies. Who was involved study? team led made up as well technical experts representatives from patient organizations (Parkinson's UK Foundation). participants were care partners. results? Slowness (called “bradykinesia”) noted key symptom. “Functional slowness” noted. symptom caused feel slower during daily tasks, such brushing teeth, walking cooking. loss ability move easily freely, termed “mobility”, also It noticeable abnormalities difficulties performing “fine motor skills”. These tasks require precision, dexterity coordination. Other impactful were: tremor, rigidity/stiffness, feelings exhaustion (fatigue), depression, sleeping problems pain. do results mean? personal views gathered wide-ranging effects Parkinson's. identifies functional slowness mobility treatments working not.
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ژورنال
عنوان ژورنال: Future Neurology
سال: 2023
ISSN: ['1748-6971', '1479-6708']
DOI: https://doi.org/10.2217/fnl-2022-0017